Ming-Hao Zheng
  1. Current research activities

    2. Our key area of research in regenerative medicine is to develop novel approaches of autologous biotherapies for bone and cartilage regeneration. Our first clinically approved product is Matrix Induced Autologous Chondrocyte Implantation. (MACI), which is the result of collaboration between Verigen and the Orthopaedic research laboratories of the University of Western Australia. To date MACI has been used in more than 70 hospitals in Australia for the treatment of cartilage injury and early degenerative joint diseases. We have also developed antologous tenocyte implantation technique for the restoration of rotator cuff tendon tear.

    Preclinical studies have been undertaken to confirm the long term durability of the technology. In collaboration with the Department of Orthopaedic Surgery, University of Lund, we have also developed autologous growth factor cocktail for the treatment of bone defect. Early stage of animal studies has confirmed the technology. In addition, we have been involved in the development of bio matrix scaffold for the induction of stem cells or lineage specific cells differentiation in vivo. Finally, molecular engineering for targeting inhibition of osteoclastic bone resorption is also our focus.

  2. Keywords

    3. Autologous biotherapies.

  3. End-user applications

    • Patients
    • Sugeons
    • Scientists

  4. Key publications

    5. I. Willers C, Chen J, Wood DJ, Xu J, Zheng MH (2004) Autologous Chondrocyte Implantation using collagen bioscaffold for treating osteochondral defects in the rabbit. Journal of Bone and Surgery (British) (submitted Jan 2004)
    II. Zheng MH, King E, Kirilak Y, Huang L, Papadimitriou JM, Wood DJ, Xu J (2004) Molecular characterisation in autologous chondrocyte implantation (ACI). International Journal of Molecular Medicine 13; 000 2004 (published Jan).
    III. Zheng MH, Wood DJ (2000) Frontiers of tissue engineering. Today’s Life Science 12: 40-44.
    IV. IV. Kumta SM, Huang L, Cheng YY, Chow LT, Lee KM, Zheng MH (2003) Expression of VEGF and MMP-9 in giant cell tumor of bone and other osteolytic lesions. Life Science 1;73(11);1427-36
    V. V. Xu J, Tan JW, Huang L, Gao XH, Laird R, Liu D, Wysocki S, Zheng MH (2000) Cloning, sequencing, and functional characterization of the rat homologue of receptor activator of NF-kb ligand (RANKL). Journal of Bone Mineral Research 15:2178-2186
    VI. Current Developments in Cartilage Transplantation, Proceedings of Round Table 77, Royal Society of Medicine Press 14th September 2002 The Basis Science of Matrices and Cellular Repair The Australian experience of ACI and MACI

  5. Outreach activities

    6. None as yet

  6. Key organisation membership

    7. None as yet

  7. Early career researcher?

    8. No.

  8. Young investigator?

    9. Yes.

  9. Skills and expertise

    • cell therapies
    • growth factor extraction
    • GMP productions
    • molecular biology techniques
    • bone pathology

  10. Specialist equipment and infrastructure

    • GMP production facilities
    • General equipment for cell and molecular biology study
    • Confocal and electron microscopes
    • BMG machine

© 2004

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