Mark Bartold
  1. Current research activities

    2. We are involved in the utilization of periodontal mesenchymal stem cells as well as autologous periodontal ligament fibroblasts, cementoblasts and osteoblasts for periodontal regeneration. We are investigating a three-pronged approach to this using

    I. Targeted cell delivery in novel biodegradable scaffolds
    II. Bilateral cell seeding on periodontal regenerative membranes
    III. Delivery of in vitro generated biomatrices incorporating specialized cells of the periodontium

  2. Keywords

    3. Mesenchymal stem cells, Periodontal regeneration, Biodegradable scaffolds,
    Cell biology

  3. End-user applications

    • Methods to repair and regenerate periodontal tissues
    • Methods to repair and regenerate peri-implant tissues

  4. Key publications

    5. I. Garraway R, Young WG, Daley T, Harbrow D, Bartold PM. An assessment of the osteoinductive potential of commercial demineralized freeze-dried bone in the murine thigh muscle model. Journal of Periodontology 69: 1325-1336; 1998.
    II. Bartold PM, McCulloch CAG, Narayanan AS, Pitaru S. Tissue engineering. A new paradigm for periodontal regeneration based on molecular and cell biology. Periodontology 2000 24: 253-269; 2000.
    III. Xiao Y, Qian H, Young WG, Bartold PM. Tissue engineering for bone regeneration using differentiated osteoblasts in collagen scaffolds. Tissue Engineering 9: 1167-1177; 2003
    IV. Xiao, Y, Haase, H, Young WG, Bartold PM. Development and transplantation of a mineralized matrix formed by osteoblasts in vitro for bone regeneration. Cell Transplantation (Accepted for publication June 18, 2003).
    V. Bartold PM, Xiao Y. Use of a matrix scaffold for tissue engineering and bone regeneration. In: Bio-Implant Interface: Improving Biomaterials and Tissue Reaction. CRC Press. JE Ellingsen, P Lyngstadaas, editors. Chapter 14, pp 247-259, 2003

  5. Outreach activities

    6. None as Yet.

  6. Key organisation membership

    7. None as Yet

  7. Early career researcher?

    8. No.

  8. Young investigator?

    9. No.

  9. Skills and expertise

    • Cell culture
    • Extracellular matrix biology
    • Periodontal regeneration
  10. Specialist equipment and infrastructure

    • Electron microscopy facilities
    • Micro CT scan facilities
    • Proteomic facility
    • General molecular biology facility
    • Micro array technology
    • Cell culture facility
    • General histology facility
  11. Contact Details 

    Professor P. Mark Bartold
    Address: Director Colgate Australian Clinical Dental Research Centre
    The University of Adelaide Department of Dentistry
    Frome Road Adelaide SA 5005
    Country: Australia
    Phone: +61 8 8303 3435
    Fax: +61 8 8303 6429
    Email: mark.bartold@adelaide.edu.au

© 2004

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