Jason White
  1. Current research activities

    2. Primarily the factors (ECM and growth factors) that regulate skeletal muscle growth and regeneration. The primary focus of my research is the cell biology of myogenesis and in particular the impact various components of the basement membrane and extracellular matrix has o0n the process of skeletal muscle formation. Another focus is the niche environmental conditions that regulate entry of stem cells into the myogenic lineage.

  2. Keywords

    3. skeletal mjuscle, regeneration, myogenesis, extracellular matrix, growth factors

  3. End-user applications

    • Increasing sheep meat yield
    • Growth factor based muscle disease therapeutics
    • Stem cells as potential therapeutic tools
    • Culture conditions which maximize myogenic cell growth
  4. Key publications

    5. I. Grounds MD, White JD, Rosenthal N, Bogoyevitch MA (2002) The role of stem cells in skeletal and cardiac muscle repair. J Histochem Cytochem 50:589-610
    II. White JD, Davies M, McGeachie J, Grounds MD (2002) An evaluation of leukaemia inhibitory factor as a potential therapeutic agent in the treatment of muscle disease. Neuromuscul Disord 12:909-916
    III. White JD, Grounds MD (2003) Harnessing the therapeutic potential of myogenic stem cells. Cytotechnology. 41:153-164
    IV. White JD, Davies M, Grounds MD (2001) Leukaemia inhibitory factor increases myoblast replication and survival and affects extracellular matrix production: combined in vivo and in vitro studies in post-natal skeletal muscle. Cell Tissue Res 306:129-141
    V. Huijbregts J, White JD, Grounds MD (2001) The absence of MyoD in regenerating skeletal muscle affects the expression pattern of basement membrane, interstitial matrix and integrin molecules that is consistent with delayed myotube formation. Acta Histochem 103:379-396

  5. Outreach activities

    6. None as Yet.

  6. Key organisation membership

    7. None as Yet.

  7. Early career researcher?

    8. No.

  8. Young investigator?

    9. Yes.

  9. Skills and expertise

    • Tissue culture · quantitative PCR
    • Muscle regeneration models
    • Growth factor/matrix bioassay
    • histology
    • immunohistochemistry
    • transgenic animal generation 
  10. Specialist equipment and infrastructure

    • FACS
    • Digital Imaging and analysis suite
    • Tissue culture
    • PC2 molecular laboratories
    • Confocal microscope
    • Small animal facilities (including surgical)
    • Large animal facilities
    • Frozen, paraffin and plastic processing and cutting

© 2004

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