Eliza Whiteside
  1. Current research activities

    2. Our group’s research focus is to establish a bioactive coating that encourages osseointegration of orthopaedic implants. We collect bone marrow samples from patients undergoing hip or knee replacements and utilising a magnetic separation technique (VarioMACS, MiltenyiBiotec) isolate mesenchymal stem cells and osteo-progenitor cells. My specific interest is investigating metalloproteases (MMPs and ADAMs) and their biological inhibitors (TIMPs) and their roles as extracellular matrix (ECM) degraders and activators of growth factors and cytokines during osseointegration and bone remodeling.

  2. Keywords

    3. matrix metalloproteases (MMPs), a disintegrin and metalloproteases (ADAMs), tissue inhibitors of metalloproteases (TIMPs), extracellular matrix (ECM), growth factors, mesenchymal stem cells, osteoblasts, bone.

  3. End-user applications

    • Orthopaedic implant coating
    • Orthopaedic fracture repair

  4. Key publications

    5. I. Whiteside EJ, Boucaut KJ, Teh A, Garcia-Aragon J, Harvey MB, Herington AC. Elevated concentration of TNF-alpha induces trophoblast differentiation in mouse blastocyst outgrowths. Cell Tissue Res. 2003 Nov;314(2):275-80
    II. Whiteside EJ, Kan M, Jackson MM, Thompson JG, McNaughton C, Herington AC, Harvey MB. Urokinase-type plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9) expression and activity during early embryo development in the cow. Anat Embryol (Berl). 2001 Dec;204(6):477 -83
    III. Whiteside EJ, Jackson MM, Herington AC, Edwards DR, Harvey MB. Matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-3 are key regulators of extracellular matrix degradation by mouse embryos. Biol Reprod. 2001 May;64(5):1331-7.
    IV. Pantaleon M, Whiteside EJ, Harvey MB, Barnard RT, Waters MJ, Kaye PL. Functional growth hormone (GH) receptors and GH are expressed by preimplantation mouse embryos: a role for GH in early embryogenesis? Proc Natl Acad Sci U S A. 1997 May 13;94(10):5125-30

  5. Outreach activities

    6. None as yet.

  6. Key organisation membership

    7. None as yet.

  7. Early career researcher?

    8. Yes.

  8. Young investigator?

    9. Yes.

  9. Skills and expertise

    • zymography
    • reverse zymography
    • VarioMACs

  10. Specialist equipment and infrastructure

    • None as yet.

     

© 2004

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