Bruce Milthorpe
  1. Current research activities

    Bone and cartilage formation from MSCs (rabbit) in bioreactor. Development of scaffold materials for use in bioreactor based on collagen and calcium phosphates. Development of environments for bone and cartilage differentiation. Development of animal models (rabbit) for testing constructs.

    Imaging of tissue engineered constructs. Use of microCT and confocal microscopy for assessing bone formation and cellular interactions.

    Biomolecular interactions with biomaterials. Measurement of interactions of biomolecules of interest with a variety of.

  2. Keywords

    Biomaterials, Interfacial interactions, scaffolds, microCT, imaging, Cytometry, bioreactors

  3. End-user applications

    • Hyaline cartilage resurfacing
    • Large defect bone replacement
    • Organ regeneration (very long term)

  4. Key publications

    5. I. Q. Garrett, R.W. Garrett, and B.K. Milthorpe. Lysozyme Sorption in Hydrogel Contact Lenses. Invest Ophthalmol Vis Sci. 40:897-903, 1999
    II. K.A. Johnson, G.J. Rogers, S.C. Roe, C.R. Howlett, M.K. Clayton, B.K. Milthorpe and K. Schindhelm. Nitrous acid pretreatment of tendon xenografts cross-linked with glutaraldehyde and sterilized with gamma irradiation. Biomaterials. 20:1003-1015, 1999
    III. X. Miao, A.J. Ruys and B.K. Milthorpe. Hydroxyapatite-316L fibre composites prepared by vibration assisted slip casting. J. Mats. Sci. 36 (13):3323-3332, July 2001
    IV. Q. Zheng, B.K. Milthorpe and A.S. Jones. Direct Neural Network Application for Automated Cell Recognition. Cytometry, 2004 (in press)
    V. A.C. Jones, D. Rohner,.D.W. Hutmacher, A. Brandwood, B.K. Milthorpe, A. Sakellariou, A. Limaye, C.H. Arns, T.J. Senden, T. Sawkins, M. A. Knackstedt Investigation of Microstructural Features in Regenerating Bone Using Micro Computed Tomography, J. Mats. Sci. Mat. Med. 2004 (in press

  5. Outreach activities

    6. None as yet.

  6. Key organisation membership

    7. Australian tissue engineering interest groups (STEAM)
    Australian Society for Biomaterials

  7. Early career researcher?

    8. No.

  8. Young investigator?

    9. No.

  9. Skills and expertise

    • physical biochemistry
    • cytometry
    • biomaterial surface interactions
    • bone replacement materials
    • bone-material interface interactions
    • bioreactors
    • biocompatibility testing
    • image analysis

  10. Specialist equipment and infrastructure

    • Animal Operating Theatre and holding facility
    • Q-Sense Quartz Crystal Microbalance
    • micro-CT
    • Radio-tracer lab
    • Flow cytometery
    • Concfocal microscopy

© 2004

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