Alan Mackay-Sim
  1. Current research activities

    2. The biology of olfactory stem cells
    The identity of olfactory stem cells
    The potency of olfactory stem cells
    Olfactory stem cells for repair in a PD rat model
    Olfactory ensheathing cells and spinal repair
    Olfactory stem cells and spinal repair
    Olfactory stem cells and repair of infracted myocardium in rats
    Olfactory stem cells as vehicles for gene therapy

  2. Keywords

    3. olfactory, stem cell, multipotent, tissue repair,_gene therapy. Parkinson’s disease, spinal repair

  3. End-user applications

    • tissue repair
    • gene therapy.
    • Parkinson’s diseas,
    • spinal repair
    • heart tissue repair

  4. Key publications

    5. I. Lu J, Féron F, Mackay-Sim A and Waite PME (2002) Olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cord. Brain 125: 14-21.
    II. Lu J, Féron F, Ho SM, Mackay-Sim A and Waite PME (2001) Transplantation of nasal olfactory tissue promotes partial recovery in paraplegic adult rats. Brain Research 889:344-357
    III. Féron F, Perry C, McGrath JJ, Mackay-Sim A (1998) New techniques for biopsy and culture of human olfactory epithelial neurons. Archives of Otolaryngology Head and Neck Surgery 124:861-866.
    IV. Murrell W, Bushell GR, Livesey J, McGrath J, MacDonald KPA, Bates PR, Mackay-Sim A (1996) Neurogenesis in adult human. NeuroReport 7:1189-1194
    V. Féron F, Mackay-Sim A, Andrieu JL, Matthaei K, Holley A, Sicard G (1999) Stress induces neurogenesis in non-neuronal cell cultures of adult olfactory epithelium. Neuroscience 88:5271-5283.

  5. Outreach activities

    6. None as yet.

  6. Key organisation membership

    7. None as yet.

  7. Early career researcher?

    8. No.

  8. Young investigator?

    9. No.

  9. Skills and expertise

    • cell culture
    • microscopy
    • patch clamping
    • embryology
    • rodent surgery
    • immunochemistry
    • micoarray

  10. Specialist equipment and infrastructure

    • Controlled atmosphere incubator
    • Electrophysiology micromanipulator
    • Rodent ventilator
    • Microarray software
    • Confocal microscope
    • Fluorescence microscope

© 2004

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